Nicotinamide-adenine dinucleotide (NADH) plays a role in the chemical processes that generate energy in the body. It also improves mental clarity, alertness, concentration, and memory.
Nicotinamide mononucleotide (NMN), a precursor to NADH, improves insulin sensitivity, controls blood sugar, eye function, mitochondrial metabolism, and gene expression.
Nicotinamide riboside (NR) also activates NADH anti-aging effects and helps with high cholesterol, high blood pressure, dementia, and obesity.
When all are combined, they repair and maintain the mitochondria, the powerhouse of the cell that is responsible for the production of ATP, the "energy molecule," that provides energy to the body. The mitochondria is also responsible for calcium homeostasis, regulation of innate immunity, and metabolism.
NMN (Nicotinamide Mononucleotide):
Nicotinamide Mononucleotide Supplementation Alleviates Doxorubicin-Induced Multi-Organ Fibrosis - PubMed
Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells - PubMed
Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise - PubMed
NMN and Fertility:
NAD+ Repletion Rescues Female Fertility during Reproductive Aging - PubMed
NMN and Degenerative Diseases:
Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes - PubMed
NMN and GI:
Nicotinamide Mononucleotide Ameliorates Sleep Deprivation-Induced Gut Microbiota Dysbiosis and Restores Colonization Resistance against Intestinal Infections - PubMed
Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide - PubMed
NMN and Metabolism:
Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism - PubMed
Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications - PubMed
Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials - PubMed
Advances in the Synthesis and Physiological Metabolic Regulation of Nicotinamide Mononucleotide - PubMed
NMN and Cardiology:
Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH - PubMed
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